You must exert prudence, however, before dashing off to the mailbox every other day, advises Yamamoto: "You should wait until you're far downstream in the negotiations" before penning notes and letters to current or future employers confirming negotiation details. "You have to know when to do these things".
Because elevated blood pressure is a systemic phenomenon, an emergent property that is far downstream from the function of individual genes, researchers are beginning to investigate the association of candidate genes with endophenotypes, or precursors to hypertension to increase the power of finding an association.
This latter STAT upregulation due to p65 overexpression is inconsistent with the structure of EGFR protein-protein interactions, in which p65 is far downstream of STAT.
The alpha lobes are far downstream from the calyx and the presumptive site of Drep2 action, and probably not important for STM.
First, the expression readout may be far downstream of the actual binding target and may lead to the pathway of action but not the direct protein target of the molecule.
In our opinion, the best phenotypes to examine in genetic analyses of renal aging should not be far downstream of the disease cascade; for example, examining nephrosclerotic changes in the early stage of their evolution and in the absence of confounding kidney disease could make detection of subtle changes possible even before they actually effect kidney function.
For T∞ < 1220 K, ignition was initiated far downstream as a dim blue premixed flame, followed by rapid upstream propagation to form an envelope flame.
Properties such as external stimuli or motor behaviors may be far "up", or "downstream" from their neural representations, depending on where in the brain data is recorded from.
The river is the source of drinking water for parts of Utah, Arizona, Nevada and California, though that water is drawn far downstream, where the concentration of pollutants is much lower.
It is likely that COX-2 and inducible nitric oxide synthase are too far downstream in the S100B-mediated pathway, and thus, we were not able to detect any significant changes when using western blotting as a relatively crude quantification method.
