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Actuarial transplantation-free survival was estimated using a Kaplan-Meier product limit estimator.
Dietary cadmium intake was estimated using a food frequency questionnaire.
Robustness was estimated using a Plackett-Burman design.
NAE was estimated using a previously described equation.
Concentration of proteins was estimated using a DCTM protein assay (Bio-Rad, USA).
The protein concentration was estimated using a Bradford Protein Assay (BioRad).
This value was estimated using a MCMC method34 that searches the feasible parameter space in pursuit of a stationary distribution.
A 95% confidence interval (CI) for the mediated effect was estimated using a bias-corrected bootstrap with 500 replications.
Areal Bone Mineral Density (BMD) was estimated using a bone densitometer.
Measurement of change in condylar position was estimated using a SAM2 articulator with condylar position indicator.
The latter was estimated using a variety of neighborhood competition indices (NCI).
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