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At least three patients were recruited at each dose level and the dose was escalated when three patients had completed two treatment cycles without DLTs.
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The Vietnam war was escalating when he was working on the "Gigantomachy" series.
Content is likely to be "escalated" when it pertains to a breaking news event say in the aftermath of a terrorist attack or when it's asked about by a journalist, a government, or a politician.
The Terror was being escalated just when danger no longer threatened the republic after French armies had prevailed against Austria at the decisive Battle of Fleurus on 8 Messidor (June 26) and long after rebel forces in the Vendée, Lyon, and elsewhere had been vanquished.
That type of privilege should only be granted when needed, when it is escalated to a sufficient level, and when it is monitored to prevent adverse actions.
When violent extremism is on the rise, when human rights are fair game, when terrorism is surging, when ethnic violent conflicts are escalating, and when thousands of men, women, and children are slaughtered, leaders of conscience must not add fuel to the raging regional fires that have been consuming us unmercifully and relentlessly.
"Drug costs are escalating, and when we hear some of the numbers employers have seen, it's scary," says Lauren Vela, a senior director with San Francisco-based Pacific Business Group on Health.
The greatest increase in LH was exhibited when doses were escalated from 12.5 to 25 mg, but the 24-h average of total testosterone only increased by 27%, suggesting a dose-limiting effect on the testosterone-producing Leydig cells of the testes, and the inability of enclomiphene citrate to stimulate the production of supernormal levels of testosterone.
IMRT has been shown to be particularly beneficial in RT of head and neck cancer where it allows sparing of the parotid glands as well as in RT of the prostate and bladder cancer where the radiation dose to the target can be escalated without increased rectal morbidity when treatment is delivered by the IMRT technique (Fig. 3).
However, despite the success of using an inhaler for pulmonary administration, similar side effects still remain for ICS, especially when the doses are escalated.
When a conflict is escalated into a costly fight then both individuals also incur fitness costs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com