Exact(6)
In the experimental group interferon dose was escalated at 6 weeks to 9 MU if HCV RNA was still detectable at 4 weeks.
infusion on day 1, was escalated at different levels according to UGT1A1 genotype.
The dose was escalated at week 12 for most patients (84 (69%) of 121) in the 60-mg/120-mg group.
In stage 1, (accelerated titration method), each dose was escalated at twice the previous dose level until drug-related toxicity ⩾grade 2 was seen in cycle 1.
Complete blood count tests were performed weekly by a central laboratory from weeks 1 to 13 and then Q3W from weeks 13 to 28 (or Q2W from weeks 13 to 27 if the dose frequency was escalated at week 7).
With a standard dose of paclitaxel at 135 mg m−2, the dosage of irinotecan was escalated at four levels: 75, 100, 125 and 150 mg m−2; 125 mg m−2 was established as the maximum tolerated dose; this dosage was administered to 46 patients.
Similar(54)
The last time we did a major assessment, in 2009, it was escalating at a rate faster and greater than we had seen previously..
Council leaders said the "roads crisis" was "escalating at an alarming rate".
Docetaxel and cisplatin were escalated at different levels in successive cohorts as a classic 3 + 3 dose escalation design.
I think it's escalating at this point.
The market is growing, the Chinese are growing affluent, the demand for horn is escalating at a horrific rate".
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