Sentence examples for was engineered to bind from inspiring English sources

The avimer C326 (AMG220), consisting of three A-domains, was engineered to bind IL-6 with picomolar affinity (Silverman et al., 2005).

The DARPin MP0112 was engineered to bind VEGF-A with a K d of 1 4 pmol/L (Souied et al., 2014b).

Based on these findings, Caf1M was engineered to bind Caf1 faster, tighter, or both faster and tighter.

The active site of the Tetrahymena ribozyme was engineered to bind an oligonucleotide derived from the 3' end of N-formyl-methionyl-tRNA fMet).

A variant, C410Y, was engineered to bind LCA with increased sensitivity (EC50 value of 3 μM and a 34-fold activation) in mammalian cell culture assays.

DX-88 was derived from the Kunitz domain of lipoprotein-associated coagulation inhibitor (LACI) and was engineered to bind kallikrein with low picomolar affinity via phage display (Williams and Baird, 2003).

It has been engineered to bind highly to penicillin binding protein 2a (PBP2a).

When introduced into an Fc fragment that had been engineered to bind to Her2/neu via a novel antigen binding site located at the C-terminus of the CH3 domain, the novel inter- and intra-domain bonds also brought about a significant increase in thermostability.

PUM-HD domains have also been engineered to bind to cytosine (which is not observed in any of the natural PUF binding specificities) and to bind targets longer than 8 bases by increasing the number of repeats [ 32, 33].

For that reason, and the lack of alternative therapies, America's Food and Drug Administration has recently agreed to expedite the review process for these two potential treatments.Unlike most antibodies, MEDI3902 is bi-specific meaning it has bi-specific meaningbitd to two different targets.

Our results also demonstrate that peptides can be engineered to bind to specific faces of COM crystals.