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YAP/TAZ nuclear accumulation (which can be indicative of increased YAP/TAZ activities) was elevated upon peripheral nerve injury in a chronic nerve injury animal model[70].
Akin to several known HDAC6 substrates such as α-tubulin, Hsp90, and Prx I, MYH9, Hsc70, and DNAJA1 were immunoprecipitated by the anti-acetyl-lysine antibody in higher amount from HDAC6 knockout mice than wild-type mice (Fig. 2A), suggesting that their acetylation abundance was elevated upon HDAC6 deficiency.
As expected, p16 was elevated upon senescence.
Spheroid's size was elevated upon thrombin stimulation and elongated in shape.
Conversely, BAG1 expression, in particular BAG1L, was elevated upon BAG3 depletion.
Although NANOG expression was elevated upon MAPK inhibition, SOX2 and POU5F1 expression showed little increase.
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NAD(P H autofluorescence measurements suggest that GLUTag and primary L cells increase their metabolic rate in response to extracellular glucose elevation, consistent with our previous observation that ATP concentrations in GLUTag cells are elevated upon exposure to 1 mmol/l glucose [ 28].
Of these, 126 unique proteins were elevated upon androgen treatment.
Moreover, 4E-BP transcript levels are elevated upon pharmacological or genetic inactivation of TOR.
Consistent with hCdc14B promoting activation of APCCdh1 [29], cyclin B levels were elevated upon depletion of hCdc14B correlating with increased Cdk1 activity (Fig. 5B and C) implying that degradation of cyclin B was impaired upon hCdc14B depletion.
In addition, Cdk2ap1 mRNA has been found to be elevated upon estrogen treatment during early implantation process, suggesting its role in uterine decidualization where the cells stop proliferation and start differentiation [16].
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