During antigen presentation, the T-epitopes are efficiently presented onto DRB1*04:11 (binder), resulting in significant T-cell activation and proliferation.
Mini-LCL pulsed with less than 1 genome equivalent (geq)/cell were recognized by all virion-specific, but not by BMRF1-specific T cells, demonstrating that virion antigens are efficiently presented on MHC II and that the number of BMRF1 molecules in virions is probably insufficient for T cell detection (Fig. 5A).
Gabathuler, R et al. report that introduction of the TAP1 gene into TAP-negative tumor cells changes the mode of antigen presentation to resemble that of TAP1-positive RMA-S cells, as indicated by the fact that a virally-derived antigen can be efficiently presented on the surface of TAP1-possitive but not TAP-negative tumor cells [14].
Moreover, ultrasound scanning techniques were efficiently presented during lectures on human models.
If the antigens reach mature DCs, they will not be efficiently presented.
Both the naturally expressed and overexpressed PTK7 were efficiently presented at the cell surface in HT1080 and PTK7 cells, respectively.
Thus, the repertoire of B cells determines which antigen is efficiently presented, particularly at low antigen doses.
As a Tc epitope, these constructs carry the ErbB2 peptide p63 71, which is efficiently presented by murine H-2Kd (Nagata et al, 1997).
According to the HLA-DRB1 allele frequency in the local population, these peptides can be efficiently presented by most (up to 84%) of study participants.
This peptide can be presented by human HLA-A2402 (Okugawa et al, 2000), but it has also been shown to be efficiently presented as an immunodominant CTL epitope by murine H-2Kd in BALB/c mice (Nagata et al, 1997).
