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In the current investigation, PSQI score in PD-C group was significantly higher than that in PD-NC group (Table 3), illustrating that the sleep quality was dramatically impaired in PD patients with constipation.
Finally, the greater osteogenic potential of frontal derived osteoblasts was dramatically impaired by knocking down FgfR1.
However, the differentiation potential of the enzymatically passaged H1 and H9 cultures as compared to manually passed H1 and H9 hESCs was dramatically impaired.
At 10°C however, there were strong differences between strains: SA strain grew better than WT strain while SE strain growth was dramatically impaired (Figure 1C, 10°C).
Investigation of muscle contraction dynamics showed that function in lmna−/− muscles was dramatically impaired at 4 5 weeks of age, as shown by the reduction in muscle specific force.
Similarly, blockade of Rok activity with the chemical inhibitor, Y-23762 (Fig. 4E, J), caused MLC-GFP to become highly diffuse, and CagA was dramatically impaired in its ability to redistribute MLC-GFP in Y-23762-treated cells (Fig. 4E, K).
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Moreover, humoral immune responses in these mice are dramatically impaired.
Normal mice have spontaneously high levels of alternation, whereas hippocampal-lesioned mice are dramatically impaired.
Protein trafficking is dramatically impaired in parasites with defective HSP101 or lacking TRX2.
Excitatory synaptic transmission is dramatically impaired by overexpression of LAR dominant-negative constructs (Dunah et al., 2005).
This SE-derived secreted factor (SE-S) was highly TLR2-dependent as responses of TLR2-deficient macrophages were dramatically impaired (Fig. 4A, and composite analysis in Fig. 4B).
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