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Beclin-1, an autophagy-promoting gene, was determined to function as a tumor suppressor after it was shown to be deleted in breast, ovarian, and prostate cancers.
The first characterized network gene, MAP3179c, was determined to function as a universal stress response gene that when bound to chromosomal DNA, initiates the SOS response.
Given the diametrically different observations on rate acceleration between TMS and DMS enolates and the chloride ion's higher nucleophilicity compared with those of bromide or iodide ions in an aprotic solvent such as DMF, and the low Lewis acidity of CaCl2, 59 chloride ion was determined to function as a Lewis base to activate the DMS enolate.
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It has since been determined to function by inhibiting cAMP phosphodiesterases [ 91], and, as a consequence, levels of NAD+ increase with concomitant increased SIRT-1 activity.
In animals, CDK4/6 and cyclin D have been determined to function in the G1 phase, human CDK2 and cyclin A/E in S and G2 phases, and CDK1 and cyclin B in the M phase [ 5, 37].
Later, PuF was determined to also function as a kinase independently of its TF activity [ 91].
The equilibrium adsorption level was determined to be a function of the solution pH, contact time, and sorbate concentration.
When expressions can be determined to be functioning in a specific disciplinary context then ambiguities tend to disappear.
Three factors were determined to be the function of parameters, such as 2,4,6-TBP concentration (X1), initial pH value (X2) and the inoculum volume (X3).
He said: "I am determined to see a functioning executive in place at Stormont.
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were determined to assess liver functions.
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