Although the creatinine value is highly specific to estimate renal dysfunction, an inadequate sensitivity of creatinine level is demonstrated, particularly in early stage AKI.
A more subtle form of extinction, genetic extinction in which the unique genome of a native taxon is lost through hybridization with closely related invaders has also been demonstrated, particularly in fish (Lockwood et al. 2007).
Yet, as in Korea, Vietnam, and countless other actions -- all undeclared wars although with a broad congressional stamp of approval -- the utility of Manning's or Snowden's leads for the Taliban or Al-Qaeda (or any regional affiliate) remains to be demonstrated, particularly since the essentials of PRISM were understood widely years ago.
However, the respective efficacy of these measures and of their combinations remains to be demonstrated, particularly in countries of high and intermediate TB endemicity [11].
The direct co-stimulation of tumor-specific effector CD4+ and CD8+ T cells (Teffs) has been demonstrated, particularly in combination with active vaccination [16], [17], [19]; yet, the in vivo effects of DTA-1 on Tregs have not been well-defined.
Before embarking on a large, multicentre RCT, the feasibility of the protocol should be demonstrated, particularly when the intervention is complex [ 15].
To attempt control, and possibly elimination, of zoonoses, benefits to public health and society need to be demonstrated, particularly in countries with scarce resources.
Nevertheless, the antimicrobial potentials of the related genus for the most active plants have been demonstrated, particularly those of genus Beilschmiedia.
The importance of this approach has been demonstrated particularly in dialysis patients, in whom rigorous limitation of salt intake and aggressive ultrafiltration were shown to prevent or reduce LV hypertrophy and dilatation, with little or no antihypertensive medication [ 71, 72].
Indeed, a close relation between PV rich fiber plexuses in layers IV and deep layer III and afferents from PV dominant thalamic nuclei has been demonstrated, particularly in the auditory system (Jones 2003).
