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If a second patient experienced DLT, then the MTD was defined Therefore, a formal sample size calculation was not applicable for phase I testing.
Dose-limiting toxicity in the form of grade 4 thrombocytopaenia was observed in one of these patients and as a result the MTD was defined, therefore, at dose level 2, that is, temozolomide 150 mg m 2 days 1 5 every 28 days and lomustine 60 mg m 2 on day 5 every 56 days.
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A book may be defined, therefore, as a written (or printed) message of considerable length, meant for public circulation and recorded on materials that are light yet durable enough to afford comparatively easy portability.
The way in which mean gravity is defined therefore determines the type of gravimetric height system.
How "rare disease" is defined therefore has major financial implications, both for pharmaceutical companies and for insurers or public drug reimbursement programs.
A kind like 'knife' is defined, therefore, not only by the intention of the designer of each of its members that it be useful for cutting but also by an operational principle known to these designers, and on which they based their design.
No information on cause of death was available; therefore, mortality was defined as all cause mortality.
Therefore, NAFLD was defined when the LAI value was <5 HU in this study.
Therefore, diabetes was defined as having either diagnosed or undiagnosed diabetes.
Therefore, CKD was defined as FHS physician-diagnosed CKD or presence of CKD by self-report.
However, computer simulations allow the true psychophysical parameters to be defined and therefore allow evaluating the estimates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com