Then, we applied the predictor to our validation set of 24 samples (Figure 3B): 75% of samples (10/14 IBCs and 8/10 nIBCs; p = 0.03, Fisher's exact test) were correctly classified, suggesting the robustness of the classifier.
As shown in Figure 3, this minigene construct is correctly spliced, suggesting that the c.442A>G mutation is unlikely to cause aberrant splicing.
However, in all species at least some group IIA introns remain, and in Rhizanthella they are correctly spliced, suggesting that another gene was responsible for group IIA intron splicing in orchids (Delannoy et al. 2011; Logacheva et al. 2011).
A demonstration that the U1-TAF15 snRNP lacks Sm proteins, but its snRNA component is correctly processed suggests that the TAF15-associated fraction of U1 snRNA follows an 'Sm-independent' processing pathway.
On the other hand in CP&RT dataset 144 probes were having SNP and 108 were predicted correctly suggesting 75% efficiency (Table 4b).
After applying our algorithm, all molecules could be fixed correctly, suggesting that when the coordinates of the studied small molecules are reasonable the prediction accuracy of our algorithm can almost achieve 100%.
This concordant finding suggests that in our series CDI was correctly classified.
Furthermore, the shorter glycans transferred to the outer surface of Chp were correctly processed, which suggests that the oligosaccharyltransferase, Glcases, Manase I, and possibly GnTase I do not require the missing branch structure for substrate recognition.
The results of both evaluations (version 0.9 and 1.0) are summarised in Figure 4. Ultimately the final version (version 1.0) was able to correctly suggest drugs of the HDF in 91.6% of all cases.
While the in vivo relevance of Bud6p phosphorylation remains to be determined, the substrate predictor correctly suggested that direct phosphorylation of polarisome proteins by Ste20p occurs in vitro, and thus presents opportunities for directed investigation of the activation mechanism of this complex.
