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Statistical analysis was completed using Microsoft Excel Microsoftt, Redmond, WA).
Repeated k-means clustering analysis of methylation occupancy was completed using seqMINER57.
For part 2, the histologic-molecular correlations study was completed using publically available TCGA data.
This retrospective study was completed using datasets from two sources (Supplementary Data Table 1).
Evaluation of the dominant slug frequency was completed using the autocorrelation coefficient and power spectrum.
The study of fracture mechanisms was completed using the double-notch four-point-bending test.
Guinea-pig atna mRNA sequence (2787 bp) was completed using RLM-RACE.
The second one was completed using a benchmark dataset for a comparison with other recent publications.
Organic fractionation was completed using liquid chromatography-organic carbon detection (LC-OCD).
SAD structure determination was completed using Phenix.autosol79 and Molecular Replacement for native structures was compiled using Phenix.phaser.phaser
Further separation of the neutral lipid fraction was completed using 0.5 g of alumina in a Pasteur pipe.
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