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The degree of agreement between the reviewers in each stage was calculated (assessed on a random sample of 10% of medical records) by using kappa coefficient.

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The interaction between ADR and GNA was calculated and assessed using a combination index (CI): CI = D1/D×1 + D2/D×2.

The prognostic 4-IHC score was calculated and assessed in a separate cohort of 786 patients.

To assess glucose variability, glucose risk index was calculated to assess glucose variability (24– 24).

The difference between C and the actual value (fractional) was calculated to assess synergy.

The positive predictive value (PPV) was calculated to assess the quality of predicted models.

The regression coefficients of total genetic value on its estimate (b) was calculated to assess unbiasedness.

A wheat-equivalent index was calculated to assess food production.

The %RSD of the experiment was calculated to assess the robustness of the method.

The Pearson's correlation coefficient (r) was calculated to assess the strength of linear dependency.

The weighted κ statistic was calculated to assess intra- and inter-group observer agreement [26].

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