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The enhanced cytotoxicity of ATO + bortezomib was associated with augmented STAT3 inhibition and JNK activation, up-regulation of Bim, p21, p27, p53 as well as down-regulation of Bcl-2.
There is evidence that Ca2+ desensitisation contributes to septic shock: in a rat model, acute endotoxaemia was associated with augmented MLCP activity and reduced sensitivity to an α1-adrenergic agonist [10].
Concomitant to deployment of the AMP generating adenylate kinase isoform network, cardiac stem cell differentiation was associated with augmented AMP nucleotide signaling, increased expression of the AMP-sensor AMPKα2, a major cardiac isoform, and nuclear redistribution of the activated and signaling competent p-AMPKα(Thr172).
This increase was associated with augmented expression of extracellular-signal-regulated kinases ERK1/2, the kinase targeting Ser31.
The increased muscle mass in mIGF-1 transgenic mice was associated with augmented force generation compared to age-matched wild type littermates [ 17].
Furthermore, pharmacological preconditioning by injection of a low dose sodium nitrite (48 nmol) into the LV of mouse hearts was associated with augmented SNO of mtCx43.
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These effects were associated with augmented intestinal MPO activity and oxidative damage such as an elevation of MDA production and a depletion of enzymatic and non-enzymatic antioxidants.
While improved glycemic control/insulin sensitivity has been associated with augmented cardiac function in pharmacologic studies, studies on dietary intervention are scarce.
Early recruitment of non-classical monocytes and their macrophage derivatives is associated with augmented tissue repair and improved integration of biomaterial constructs.
Hypertension induced by long-term infusion of angiotensin II (Ang II) is associated with augmented intrarenal Ang II levels to a greater extent than can be explained on the basis of the circulating Ang II levels.
There is considerable evidence, both in humans and animals that IFN-γ production is necessary for protective immunity against mycobacterial disease [18] [21] and successful chemotherapy of TB is associated with augmented IFN-γ production [22] [24].
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