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The twins' academic performance was assessed throughout the school year by their teachers, using the assessment materials of the National Curriculum for England and Wales (NC), the core academic curriculum developed by the Qualifications and Curriculum Authority (QCA) [26].
Safety was assessed throughout the study by physical examinations, recording of vital signs, toxicity assessments, and laboratory tests (hematology, clinical chemistry).
Additionally, the level of gastrointestinal nematode infections of the herd was assessed throughout the study.
Bone formation was assessed throughout the study via radiography, and following euthanasia, via microcomputed tomography and histology.
Level of anaesthesia was assessed throughout the experiment by monitoring reflex withdrawal to a hindpaw pinch.
Protection was measured by monitoring animal survival and body weight, which was assessed throughout an observation period of 21 days.
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Women also need to be assessed throughout pregnancy and to be aware that, if their risk profile increases, they may need to change their plans.
Adverse events (AEs) were assessed throughout the study.
The safety and tolerability were assessed throughout the study.
Milk yields and composition were assessed throughout the study.
AEs were assessed throughout the entire study by means of a non-leading open question.
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