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To be sure, Picasso's work had been seen in England since 1910 and his influence on a handful of young British artists was already detectable a year or two later.
In human breast carcinoma cells, MDA-MB-231 Trexpressionsion began to increase only at 15 Gy and reached levels sufficient to markedly decrease cytosolic dsDNA at 18 Gy (Fig. 8a), while in human breast carcinoma cells 4175TR a slight increase in Trex1 expression was already detectable at 10 Gy and reached levels sufficient to markedly decrease cytosolic dsDNA at 12 Gy (Fig. 8b).
Retrospective analyses (by nested PCR) at the time point, when bone marrow sampled in the third week of life was MLL-rearrangement-negative by FISH, showed that the MLL-AF10 fusion transcript was already detectable back then, 4 months prior to the definitive diagnosis of AML in the bone marrow (Table 1).
During embryonic kidney development, cadherin-9 expression was already detectable at the 6th week of gestation (Fig. 2A).
However after administration of TAM, positive recombination was already detectable after 4 hours whereas widespread EGFP expression could be observed after 6 hours (Fig. 3c).
The blockade of TLR9-mediated production of IFN-α, effective only when pDCs were exposed to virus prior to or shortly after CpG-A stimulation, was already detectable at the IFN-α transcription level 2 h after stimulation with CpG-A and correlated with down-regulation of the transcription factor IRF7 expression and of TLR9 expression.
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Autoantibodies to p53-10 were detected in 23 colorectal cancer cases and were already detectable in 10 of the patients at the time the first serum sample was collected, a median of 2.1 years (range 1.0 3.8) before diagnosis.
Myostatin inhibitors are listed on Wada's prohibited list and they are already detectable using standard laboratory techniques.
A group of geoscientists suggest that human activities, including those contributing to climate change, have altered the planet so much that their consequences are already detectable in the geological record and are reason to consider that sometime in the mid-twentieth century Earth moved into a new geologic epoch: the "Anthropocene".
Some effects of ocean acidification are already detectable.
Both, 15/3/6- and KLH-specific Abs were already detectable at a concentration of 0.05 µg/ml and their levels increased in a dose-dependent manner (Figure 2).
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