There was a marked time-dependency of the sensitivity of these cells, with 99% of cells killed by a 24-h exposure to 10 n M CPT but only 45% killed by a 1-h exposure to the same concentration of CPT.
As described above, there was a marked increase over time in the likelihood that Ontario legionellosis cases were identified by urine antigen testing, with or without other complementary testing methods.
When the same areas were imaged at 0, 6 and 24 hours after photoswitching, there was a marked decrease over time in the number of red, photoswitched cancer cells in well-vascularized regions, suggesting that the vascular environment supported the disappearance of the cancer cells through intravasation.
Nevertheless, there is still a marked time delay between patient's actions and the BCI's responses.
The number of jobs was little changed, but there was a marked shift from full-time to part-time employment.
There was a marked dose- and time-dependent decrease in Mcl-1 expression in cells treated with AT-101.
There was a marked improvement in documentation over time for most specific disease related signs such as conscious level, chest indrawing, and skin turgor (table 3).
At the same time, there was a marked increase in papers by newcomers to the field, who were less likely to cite the work of the deceased eminence.
A Republican aide assigned to help work with speakers in 1996 and this year said there was a marked difference in the process this time.
But Peter Hunt, a spokesman for ConocoPhillips Canada in Calgary, said, "Last time there was a marked increase in exploratory drilling due to higher prices, all that we managed to do was to replace what we were already producing".
At the same time, there was a marked drop in coverage of scientific news generally, and an eighty-per-cent decrease in climate-change coverage in particular, according to a government report released in 2010.
