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'was a huge setback' is correct and usable in written English.
You can use it when you want to refer to a significant problem or obstacle that has made progress difficult or stopped it altogether. For example: The closure of the factory due to the economic recession was a huge setback for the city's economic growth.
Exact(21)
It was a huge setback.
"It was a huge setback," he said.
This was a huge setback this week, with the Voting Rights Act".
This was a huge setback for Obama's outreach strategy to Iran.
The loss of Kismayo was a huge setback for the Shabab, and the United Nations Security Council passed a resolution last year banning imports of Somali charcoal.
Instead, Israel's storming of a Turkish-flagged vessel in international waters was a huge setback to efforts to win new sanctions on Iran.
Similar(37)
It would be a huge setback".
But that would be a huge setback.
A loss would be a huge setback".
If Newcastle lose it will be a huge setback.
"It's a huge setback," Coach Jeff Van Gundy said.
More suggestions(16)
was a huge inconvenience
was a huge collapse
was a huge reversal
was a huge downturn
was a massive setback
was a huge backlash
was a huge obstacle
was a big setback
was a huge disappointment
was a huge defeat
was a huge blow
was a huge game
was a huge day
was a huge save
was a huge inspiration
was a peculiar setback
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com