The low resolution of this crystal structure (3.6 Å) and poor data quality did not warrant refinement past the initial molecular replacement solution.
The technique described is promising, but warrants further refinement before it can be recommended for widespread clinical use.
Although the results suggest a plausible CRBN-dependent mechanism, our experimental model warrants further refinement to overcome the limitations encountered in the present study.
Both non-invasive techniques assessing vascular function warrant further refinement to better assist preoperative optimization strategies aimed at improving perioperative vascular function.
Currently, we do not have sufficient dose response clinical data available in the literature to warrant model refinement based on the data.
Although, non-invasive techniques assessing vascular function warrant further refinement, we conclude that BART and DTM are useful diagnostic tools for assisting preoperative optimization strategies aimed at improving vascular function in patients undergoing major surgery.
However, the data analysis showed that the categories of Judgement and Appreciation warranted further refinements, which are discussed below.
Job projections would probably rise slightly if we specifically allocated $50 million per year for administration, technical assistance and workforce training because these labor intensive activities result in a higher number of jobs per million dollars of investment.9 However, there is insufficient information to warrant this additional refinement of our estimates.
Identification mechanisms for eating episodes and image deletion functioned, but warranted additional design refinement to enhance user-friendliness and maximal use of the images.
We are aware of the small cohort of patients in this study, which limits the power of multivariate analyses and thus warrant validation and refinement by larger scale prospective trials.
Given the critical involvement of cortical functioning in learning and memory, Golgi analyses of cortical cell morphology is warranted; however, further refinement of a possible localized cortical target would significantly improve the ability to detect biologically meaningful changes.
