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Weight loss is associated with significant but small changes in DNAm across the genome, and weight loss outcome is associated with individual differences in baseline DNAm at several genomic locations.The identified weight loss associated DNAm markers, especially those showing reproducibility across different studies, warrant validation by further studies with robust design and adequate power.
These preliminary results warrant validation studies at other medical centers.
Our findings warrant validation in large prospective studies where complete data on molecular subtypes are available.
In addition to the myosin and actin, we also prioritized proteins from our catalogue via manual inspection seeking to select other candidate biomarker proteins warranting validation.
These results warrant validation through comparisons on real data.
Thus, our findings warrant validation in larger independent clinical studies.
Therefore, these preliminary results warrant validation in larger trials.
These preliminary results warrant validation in larger trials.
These preliminary findings warrant validation in a separate cohort.
Moreover, our observations warrant validation in large, independent cohorts.
These results warrant validation in a control trial.
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