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Further investigation of regulatory T cell responses in both malaria vaccinated and non-vaccinated children are warranted, Measurement of gene expression of a panel of key cytokines over several timepoints by real-time RT-PCR provides a method of monitoring cellular responses to vaccination, and represents a method for detailed analysis of samples obtained in a field setting.
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Nevertheless, the emergent outcomes that may occur independent of symptom relief and enhanced physical functioning are relevant and legitimate PROs that warrant measurement in valid and reliable ways.
Only properly-signed estimates should be introduced, and special caution is warranted for measurement error covariances because the measurement error variables in structural equation models are beyond, or are external to, the substantive modeled latent theory, and hence covariances between error variables often lack substantive theoretical grounding.
Cognitive function is also affected by pain [26] complicating assessment further, warranting baseline measurement before any pharmacotherapy is considered.
These findings warrant the measurement and enhancement of PA after hospital discharge.
Consensus and standardization of technique of alpha angle measurement is warranted, not only for planar measurements but also for CT or MRI-based measurements.
Monitoring is used to detect a rise in blood pressure above a certain threshold level (typically 140/90 mm Hg) that acts as a signal warranting re-measurement or adjustment of treatment.
Further investigation of the relation between phagocytes, NK cells, T cells and ROS in blood and tumour tissue is warranted, including direct measurements of apoptosis and ROS levels.
Further research on the value of TEG/ROTEM in sepsis is warranted, and sequential measurements are needed to understand the coagulation patterns, as can be detected by TEG/ROTEM.
However, it is warranted to validate the measurement of cortisol in hair in comparison to other indicators of extended stress.
Prospective interventional trials are warranted to elucidate if measurement of copeptin provides additional information beyond established risk tools that impact treatment decisions which might improve patient outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com