Technical progression in the field of radiotherapy has facilitated a more precise localised delivery of radiation and thus warranted dose-intensification at the site of the tumor.
The ADM processing logic should be designed to proactively alert clinicians when changes in patient criteria might warrant dosing changes based on the configured clinical knowledge base.
19 Furthermore, the increase in starting doses of statins during the observation period is also in accordance with newer treatment guidelines; 22 further examination of the impact on the changed starting doses over time is warranted, as dose is related to efficacy in lowering cholesterol.
Grade 3 nonhaematological toxicity or nadir neutrophil counts <0.5 × 10 or platelets <50 × 10 l−1 warranted 5FU dose reduction by 50 mg m−2.
Significant interpatient variability with apatinib warrants dose modification to meet individual needs.
It is unknown if the final marketed dose of rilpivirine 25 mg once daily warrants dose adjustment when these two drugs are coadministered.
However, significant thrombocytopenia occurred in many patients, thus warranting a dose adjustment or an alternative dosing schedule in further studies to receive a better safety profile.
One of eight patients on Schedule 4/2 experienced a DLT (grade 3 neutropenia) at the initial dose level of sunitinib 37.5 mg+gemcitabine 750 mg m−2 ,warranting further dose escalation.
In Germany, patients must be hospitalized for at least 48 h until the dose rate (measured at a distance of 2 m) is below a level warranting the dose to the public to stay below 1 mSv per year.
They were determining whether my white blood cells were low enough to warrant the dose of Neulasta, a drug used to boost chemo patients' white blood cell count so they can be strong enough to continue the chemo regimens.
