Clinicians should be aware that a lack of marked improvement within 24 h of initiating antimicrobial therapy is not uncommon and in itself, does not warrant switching or changing the antimicrobial therapy.
Clinically warranted switches often confer tangible benefits by enhancing treatment effectiveness and tolerability, and overall treatment acceptance by patients [ 4, 6, 11].
To see how high the risk of progression to ESRD under lithium treatment would have to be to warrant a switch to ACs, we extended the range of the sensitivity analysis and found a threshold value of 41.3%, beyond which the model advised to change the strategy (Fig. 3).
Let one of them send in a cereal-box top for a space ring, & a 2-week delay may evidence enough of gross managerial incompetence to warrant his switching his allegiance from General Foods (now selling for around _&92, to Kellog (unlisted).
But he says it remains to be seen whether the technique will be cost-efficient enough to warrant researchers switching to it.
The results of this study indicate that these processes may be significant enough to cause failure of ARV therapy after a few months, warranting a switch to second line ART.
Empirical addition of a glycopeptide, if not used initially, may be warranted, and switching from piperacillin-tazobactam or a third-generation cephalosporin to a carbapenem as second-line therapy should be considered (Figure 1).
Empirical addition of a glycopeptide, if not used initially, may be warranted, and switching from piperacillin-tazobactam or a third-generation cephalosporin to a carbapenem as second-line therapy should be considered.
In response, companies created dead man's switches, or "warrant canaries".
Barring clinically significant adverse events, patients remained on their initial medications for at least 8 weeks, after which they could change medications if a switch was clinically warranted.
