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The greatest athlete in the world but let's face it - those ears, the dorky grin... substitution warranted?? (I don't mean that Brad Pitt should get the medals - although perhaps he could have a copy)." I reckon it's some of the events that lack spark.
Amino acid replacements among β-tubulin sequences are scarce; those that occur are generally idiosyncratic but certain substitutions warrant further analysis.
Notwithstanding some limitations, the study in Critical Care by Peng and coworkers [ 1] supports the idea that acute (necrotic/infected) pancreatitis can result in CIRCI following relative adrenal insufficiency, that the ACTH test can help to recognise it, and that the condition likely warrants treatment with substitution doses of corticosteroids.
The presence of Ser (S) in place of the consensus N6 in the second TPR motif of AtPhox1 and AtPhox4 (Table 2) warrants investigation of this substitution in the context of Hsp90/Hsp70 binding.
Thus, caution is warranted when considering generic substitution of drugs that exhibit high interindividual variability or differing PK properties in different patient populations because this variability cannot be addressed by narrowing BE boundaries.
Another limitation warranting further study is the substitution of cost for charge in our analyses.
However, the contrast between rates of non-synonymous substitution and of ω warrants some caution in drawing firm conclusions.
Consultation with dietitians who are familiar with Chinese food preferences and can offer culturally acceptable food substitutions is warranted.
Since the p.S434S variation does not predict an amino acid substitution, analysis by PolyPhen and SIFT is not warranted.
Further in vivo work to unravel the pathophysiological significance of Pro143Ala substitution and its relationship with mitochondrial dysfunction is warranted.
Ongoing monitoring of the impact of opiate substitution treatment on mortality in the UK and other countries is warranted, particularly investigation of specific causes of death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com