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During the operation, rats were placed on a warm mattress to limit heat loss and chloramphenicol (20 mg/g) eye drops were administered to prevent dehydration of the eyes.
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Body temperature was maintained at 37.5°C ± 0.5°C by the use of a warming mattress and a patient air warming system (Warm Touch 5700; Mallinckrodt, Hennef, Germany).
Rat cages were kept on a warmed mattress for the first day.
During the HIPEC procedure, rats were removed from the warmed mattress to prevent general hyperthermia.
During the operation, rats were placed on a warmed mattress to limit body heat loss.
During the surgical procedure, with an average duration of 60 75 min, rats were kept at a constant temperature using a warmed mattress.
Warming is provided by a neonatal warming mattress with Inditherm proprietary carbon polymer using low voltage electrical power, the temperature range of this mattress is adjustable between 35°C and 40°C.
Eight healthy volunteers participated on four study days: (1) control, (2) skin warming (with forced air and warming mattress), (3) meperidine (target plasma level: 0.9 μg/ml), and (4) skin warming plus meperidine (target plasma level: 0.9 μg/ml).
During the total procedure, which took on average 2 h and 20 min, rats were kept at a constant temperature with a warmed mattress and a heat producing light bulb.
New equipment, such as infusion pumps [ 4], warming mattresses and temperature probes are now available.
To keep the rat's hind limb at a constant temperature of 38 39°C, a warm water mattress was applied.
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