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"waning effectiveness" is a correct and usable phrase in written English
It means a decrease in the extent to which something is successful or productive. Example: The government's efforts to control the spread of COVID-19 showed signs of waning effectiveness as the number of cases continued to rise despite strict measures.
Exact(6)
But we do have at least five years of safety data that include no hints of long-term risks or waning effectiveness.
Childhood vaccination with Bacillus Calmette-Guérin has been reported to significantly reduce the rate of tuberculous meningitis, but its waning effectiveness in adulthood has prompted a search for a better vaccine.
Estimates of vaccine efficacy for children aged 2-4 years take into account the waning effectiveness of the vaccine.
First, drug holidays anecdotally have been used to counteract waning effectiveness after a period of continuous use; perhaps by interrupting the development of possible tolerance and/or the need to continually increase the dose over time.
In vaccinated children <2 years, vaccination was assumed to directly reduce the probability of pneumococcal infection by the recorded efficacy of the vaccine [ 23] for children 2 - 4 years; efficacy was reduced to reflect waning effectiveness of the vaccine over time [ 22].
They also tested for a relationship between the number of doses and effectiveness, and for possible waning effectiveness one year after vaccination.
Similar(54)
Despite his waning popularity and effectiveness, they failed to oust him via a secret no-confidence vote on Oct. 1.
Al Qaeda has operated there since the early 1990s, with its strength waxing and waning depending on the effectiveness of the government's counterterrorism efforts.
Moreover, the waning of effectiveness of infant-only scheduled vaccination will be a focal point for future evaluation.
But although state television can still transmit the Kremlin's message, its effectiveness is waning.
Douglas said the same, but his confidence seems to be waning, along with his effectiveness.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com