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The primary outcome is change in six-minute walk distance at 12-week follow-up.
The primary endpoint was absolute change in 6-min walk distance (6MWD) over 48 weeks.
Six-minute walk distance in persons with Parkinson disease: a hierarchical regression model.
Other endpoints included sputum conversion, 6-minute walk distance, and adverse events.
When dosed for up to 120 weeks, stabilization of 6 min walk distance was demonstrated in a Phase 2b study.
Six-minute walk distance increased for all patients in all age categories across programs after CR (P <.0001).
The median 6-min walk distance was 72%% of predicted.
Blacks had shorter 6-minute walk distance and lower peak VO2 at baseline.
Timed walk distance improved to a similar degree in all subgroups (26 to 36%).
The 6-minute walk distance increased with MSCs only (repeated measures model, P = .03).03
The mean improvement in walk distance was 49.0 m (90% confidence interval, 17.5 to 84.0 m).
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