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In particular, cancer cells expressing the most sensitive IP3R isoform (IP3R2) likely are very vulnerable toward tonic IP3 signaling.
The presence of IP3R2 rendered these cells vulnerable toward ongoing IP3 signaling, for example, like during chronic activation, whereas cells expressing relatively low levels of IP3R2 were much less sensitive.
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They will have the job of protecting the withdrawal of the British army's heavy equipment when it leaves from either the airport or on vulnerable roads toward Kuwait and the port of Umm Qasr.
[5:13 p.m. | Insert | Please be sure to read "Climate Change Given Prominence in Obama's Address" for political context and subtexts.] The only plausible approach is a stepwise policy, building from smart near-term steps that can be sold to many constituencies for many reasons (energy efficiency, boosting resilience to climate hazards in vulnerable places) toward the tougher ones.
This raises the question whether cancer cells, in particular Bcl-2-dependent malignancies, displayed altered Ca2+-signaling properties that turned these cells into vulnerable targets toward peptides disrupting Bcl-2-mediated suppression of apoptotic IP3R activity.
The exposing of indifference and cruelty toward vulnerable men, in "Titicut Follies," or toward animals, in "Primate" (1974), lent those films a fortifying ire, whereas the new work radiates benevolence toward an institution that is itself benign, and where's the rub in that?
Bullying, intentional harm-doing or harassment that is directed toward vulnerable targets and typically repeated.
The models' sympathizers say that the industry is known for its rapacious attitude toward vulnerable young people and that it has long lacked professionalism.
The well-trained German soldiers crawled out of their dugouts and let loose with rifle, machine gun and artillery fire against the vulnerable Tommies advancing toward them.
The Baby P effect has also helped create a climate in which many more children are removed into care and attitudes toward vulnerable working class parents in need of support have hardened.
CHICAGO — Trying to spark what he called "a sustained national conversation" about youth violence, Attorney General Eric H. Holder Jr. met with public school students and elected officials here Wednesday, pledging a heightened crime-fighting commitment from the federal government toward vulnerable children.
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