Of the two components of the activation/repression switch, the repression may be vulnerable to the X chromosome-specific mechanism of dosage compensation that broadly and ubiquitously activates X-linked genes in somatic cells [ 44].
In vitro data support that cell lines lacking MMP−9 and −2 are much less vulnerable to the immunotoxin, and that specific MMP inhibitors partially protect cells expressing the proteases from the immunotoxin.
Our in vitro data provide an appropriate explanation by demonstrating that Twist1-overexpressing AML cells are more vulnerable to the cytotoxicity of phase-specific cytarabine through suppression of cell cycle regulator p16.
These data imply that by supressing p14 and p16 expression, Twist1 promotes cell cycle entry and renders leukemic cells more vulnerable to the cytotoxicity of phase-specific chemotherapeutic agent cytarabine.
In the present study, we explored the hypothesis that neonatal cerebellar structure and motor coordination may be particularly vulnerable to the effects of hypergravity during specific developmental stages.
Although there is general understanding about which subgroups are more vulnerable to specific events, the lack of specific information means that early warning systems are missing opportunities to ensure that those most at risk know appropriate actions to reduce the likelihood of suffering adverse impacts.
While the player is free to proceed through the game in any order, each Robot Master is especially vulnerable to a specific weapon, which encourages the player to complete certain stages before others.
In my memoir, Shoes of a Servant -- My Unconditional Devotion to a Lie, you can see how vulnerable I was to the specific type of manipulative tactics used by Sun Myung Moon and his followers and how I became an extremist.
Once you start segmenting the market so that only those vulnerable to a specific condition can buy coverage for that condition, the cost of that coverage soars into outer space. .
The network was strong, well funded, but especially vulnerable to a specific attack.
