They are typically observed as gaps and constrictions of metaphase chromosomes, and the vulnerable loci are called common fragile site (CFS).
In Lewy body disease, cell clusters that are particularly vulnerable include the locus coeruleus, the raphe nucleus, the tuberomammillary nucleus of the hypothalamus, the periaqueductal gray and the basal forebrain [ 25, 47].
I suspect women today may be particularly vulnerable to placing the locus of illness in their heads rather than their bodies.
Our studies support the proposition that specific loci are vulnerable during certain types of DNA damage.
As natural selection in crop wild hybrid zones ultimately dictates crop toward wild introgression, our overall selection analyses results—selection favoring earlier spring emergence and greater seedling size (Tables 1 and 2), both crop-like traits—suggest that wild sunflower genes encoding spring emergence and seedling size, and linked genetic loci, are vulnerable to genetic assimilation.
Keller and Miller noted that complex behaviors (which would extend to language, intelligence, and social behavior) involve integrating many complex pathways and so are potentially vulnerable to mutations at many loci.
Although we do not have an explanation for these organ-specific effects, it is tempting to speculate that either some loci are more vulnerable to environmental factors than others, or that specifically regulated mechanisms, such as preferential perfusion of the brain or reduced blood flow to the liver during placental dysfunction act on the epigenome.
Hence, deletion of the ATM gene results in genomic instability, which may be manifested by the acquisition of various additional aberrations, including deletions in vulnerable regions, such as the 13q14 locus.
However, any conclusions involving individual gene loci in clinical isolates are vulnerable to phenotypic results that arise from mutations elsewhere in the genome.
The 15 microsatellite loci characterized herein for the vulnerable forb S. macrocarpus are being used for research to document the population structure, gene flow, and breeding system, and to assess population viability of current and future populations.
