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Adequate methods of allocation generation were described in two studies, adequate methods of concealment in one study and adequate losses to follow-up in 3.
66 70 Twelve trials had adequate methods of randomisation, 39 40 66 70 71 72 74 75 77 78 79 80 and 10 of these had adequate allocation concealment.
One study described adequate methods of allocation generation, one described adequate methods of concealment, and both described adequate losses to follow-up.
All studies used adequate methods of sequence generation and had adequate concealment of allocations prior to assignment.
In 16 (23%) studies adequate methods of sequence generation were described.
The main vulnerability of these methods is in the robustness of the watermarking method.
This condition shows vulnerability of some methods, but it is easily avoidable in controlled test environments.
Consequently, adequate methods should be urgently developed.
We believe that an adequate method of constructing proper controls is needed.
Six studies described an adequate method of randomisation.
Therefore, an adequate method for their determination is of importance.
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CEO of Professional Science Editing for Scientists @ prosciediting.com