To determine whether the widely accepted concept of using lower tidal volume (Vt) values in patients with ARDS or obstructive lung disease has affected the pattern of ventilator settings in mechanically ventilated patients who do not have one of these conditions.
Comparisons between patients with MS and control subjects were made for BPND and VT values, respectively.
The range of VT values was not wide across regions (0.70 to 1.46 mL/cm3).
VT values from the SA method demonstrated an overall constant and small negative bias (−0.76%) compared to theoretical values.
PCAs were performed independently for PET1 and PET2 after z-score standardisation of VT values within genotype groups.
There were no significant differences in the BPND or VT values between patients with MS and healthy controls.
Robust BPND and VT values could not be obtained for most MS lesions due to noisy time-activity curves.
PET imaging in isoflurane-anesthetized baboons with high specific activity [11C]GMOM provided fairly uniform regional brain distribution volume (VT) values (12.8 17.1 ml g−1).
Cerebellum could be considered an intermediate region, both in terms of VT values (Table 3) and in differences between the models (−8.0%).
Regional differences in VT values estimated from the three different models (1TCM, 2TCM, and SA) were tested for significance by repeated measures ANOVA and subsequent paired t tests.
