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Although, age and sex distribution in the study subjects were comparable with those of the general population, suggesting that the present study overcame volunteer effects in part.
However, due to volunteer effects and to the unique environment of a randomized controlled trial setting, the applicability of these findings to a real world setting remains uncertain.
Because all four sites are involved in both "on" and "off" phases, this particular study design also balances case mix and controls for Hawthorne or volunteer effects, as well as issues related to "institutional learning" over time [ 39, 40, 42].
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This cross-sectional descriptive analysis sought to determine if a healthy volunteer effect can be demonstrated among smokers selected to participate in a dietary intervention trial.
Second, like other volunteer studies, the LongROAD study is likely to include participants that are healthier than the general population (the "healthy volunteer effect").
The "healthy volunteer effect" could be intensified by the reliance on healthcare systems for recruiting study participants because healthcare utilizers are on average healthier and more affluent than non-utilizers (Schneeweiss and Avorn 2005).
No other healthy volunteer effect was allowed for.
Rates were reduced by 20% for a healthy volunteer effect.
However, a problem for the generalization of results from prediction models is posed by the so-called healthy volunteer effect.
However, it is likely that a similar healthy volunteer effect exists in individuals enrolled in screening programmes for colorectal cancer.
This phenomenon, which we term "healthy person non-visitor effect", is perhaps similar in conceptual moorings to the well-known "healthy volunteer effect".
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