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For the antitumour efficacy data, the primary end point (time to reach four times the original tumour volume) was analysed using the Cox proportional hazards model to compare groups.
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The diffusional interactions between a solid body and a fluid of finite extent which is sampled either continuously or intermittently, with or without replacement of the sampled volume, are analysed using perturbation techniques.
Tumour-free survival and comparisons of tumour numbers and tumour volume were analysed using GraphPad Prism4 software.
Image volumes were analysed using a Fiji/ImageJ macro script that automated the analysis (available upon request).
Vascular volumes were analysed using an axial strip sampling technique (Mayhew and Sharma, 1984).
The diagnostic utility of ANP and BNP in predicting volume overload and survival was analysed using the Receiver Operating Characteristics curve (ROC) analysis.
Pore size distribution in cements was analysed using volume-equivalent sphere diameter and counting the number of pores within different ranges.
Once concentrated to a volume of 0.2 mL, this fraction was analysed using GC-MS [ 37].
A. The kinetics of HES was analysed using a one-volume fluid-space model.
The differential equation is: d v c d t = R o - k o - k 10 (v c - V c ) B. The kinetics of Ringer´s acetate was analysed using a two-volume fluid-space model, modified to allow for unbalanced distribution of fluid between Vc and a peripheral compartment, (Vp).
Data was analysed using R and BioConductor.
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