Different variables were used to define these, including the volume of fluids needed for resuscitation, the time taken for haemodynamic stabilisation, the need for "rescue" fluids, acid-base normalisation and recovery, duration of shock, and any subsequent episodes of shock.
The massive amount of fluid needed during resuscitation, particularly in larger burns, creates a generalised oedema that is caused both by the volume of fluid itself and the decreased colloid osmotic pressure that will ensue secondary to the resuscitation fluid given and to proteins lost from the circulation [ 3, 4].
Also, the daily amount of study drug did not decrease over time in this trial, although the amount of fluids needed for acute volume resuscitation is theoretically supposed to decrease day by day, as septic patients can typically be stabilised within 48 to 72 h.
With intermittent hemodialysis, large volumes of fluid need to be removed over a relatively short period of time, jeopardizing hemodynamic stability in already hemodynamically compromised patients.
From a physiological point of view, acute volume resuscitation with colloids should result in less amounts of fluids needed for haemodynamic stabilisation compared to crystalloids [ 25].
Such a strategy minimizes risk exposure when considering that a limited volume of fluids is needed in this indication (about 1000 to 1500 ml within several hours) and will not have deleterious consequences, except for patients with cardiac insufficiency or fluid overload.
The microcirculatory changes in animals with 60 minutes occlusion were accompanied by progressive metabolic acidosis, substantially larger volumes of intravenous fluids needed to support arterial blood pressure and significantly reduced survival (30%).
Computational Fluid Dynamics (CFD) was used to predict velocity profiles, Power Numbers, and Pumping Numbers using a multiple reference frame (MRF) model coupled, when needed, with a Volume of Fluid (VOF) model.
This is based on determining the time needed for a given volume of fluid passing between two points marked on the instrument.
