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Taking the longer gestation period of human beings, a longer time of exposure per day and a larger volume of breathing into consideration, the inhalation dose used in the present study was not far from reality.
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First, dynamic hyperinflation shifts tidal breathing to a less compliant part of the respiratory system pressure-volume curve leading to an increased pressure-volume work of breathing.
This volume lies within the tidal volume of spontaneously breathing mice [ 16, 17].
HFO = high-frequency oscillatory; HFOV = high-frequency oscillatory ventilation; Pett = pressure at end of the tracheal tube; Pprox = proximal airway pressure; PTP = pressure time product; Vt = tidal volume; WOB = work of breathing.
CDP = continuous distending pressure; HFOV = high-frequency oscillatory ventilation; MAP = mean airway pressure; ΔMAPEXP = maximum deviation from the mean airway pressure during expiration; ΔMAPINSP = maximum deviation from the mean airway pressure during inspiration; PETT = pressure at end tracheal tube; PTM = transmural pressure; VT = tidal volume; WOB = work of breathing.
The test concentration was chosen as to be representative of the volume of air breathed during a work shift, that is, assumed to be for construction workers of about 1.4 m/hour of work [ 29, 30].
To study the effect of breathing motion on gross tumor volume (GTV) coverage for lung tumors using dose-volume histograms and relevant dosimetric indices.
However, the tidal volumes we used are in the range of tidal volumes of spontaneously breathing mice [ 16, 17].
Though arbitrary, VT values < 8 mL/kg PBW are more similar than 8-10 mL/kg PBW to the resting tidal volumes of spontaneously breathing adults (7-8 mL/kg) and also to those VT values shown to be protective in ARDS patients [ 5, 7].
The increase in lung volume tends to increase airway caliber and consequently reduce the resistive work of breathing.
The work of breathing esophageal referent (WOB_Peso, j/l)) is obtained from integral of Peso versus differential of volume.
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