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Metoclopramide was dissolved in physiological saline solution, and the volume of administration was at 5 ml/kg body weight.
Due to their low volume of administration, coagulation factor concentrates are also likely to have a smaller effect on haematocrit.
Despite the fact that colloids are widely used, doubt still remains as to which colloid is the best and what is the ideal volume of administration.
The volume of injection required per dose was also analyzed, because higher dose levels imply higher volume of administration and greater patient discomfort.
As per the OECD guideline the extract doses to be administered were determined based on the acute toxicity study and volume of administration was 1 ml/100 g of body weight of the animal [ 27].
PCCs can also be infused faster than human plasma, have a reduced volume of administration (and therefore, unlike FFP, are not associated with volume overload), are associated with a shorter preparation time (since some PCCs can be stored and reconstituted at room temperature, whereas FFP needs to be thawed prior to use), and do not require blood-group matching [ 1].
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The maximum volumes of administration in mice used to be 5 ml/100g.
Table 1 Animal protocol design represents groups of animals and their test drug dosages administered to mice Groups Treatment Dose Dose volume Routes of administration I Disease control (depression induced) Saline 1 ml Oral II Normal – – – III Standard lithium carbonate 100 mg/kg 300 mg/kg 1 ml Oral IV Test nanocomposite 10 mg/kg 1 ml Oral.
Based on this finding, the TGA may be beneficial in that it can help to identify the real-time effect of FFP administration on PS level and clarify the most appropriate times and volume of FFP administration in PS deficiency patients.
These groups required a larger volume of fluid administration to maintain cardiac output compared to the sham group (1,001 ± 246, 938 ± 170, and 376 ± 105 mL, respectively, P < 0.0001).
Although fresh frozen plasma (FFP) is rich in PS and is often used in cardiac surgery for patients with PS deficiency [3, 4], the most appropriate times and volume of its administration to prevent thromboembolism remain to be clarified.
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