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The potential confounding effect of tumor volume (day 0 or at sacrifice) was evaluated using multiple linear regression, and the estimated time trends were essentially the same as without adjustment for tumor volume (data not shown).
Since short-term treatment with 50 mg/kg inhibitors did not cause any significant changes in tumor volume (data not shown), long-term studies were performed with high-dose treatment to confirm that H1975 (Fig. 3a) and H1993 (Fig. 3b) tumors were resistant to erlotinib and sensitive to WZ4002 or crizotinib, respectively.
We also examined the relation of PBL telomere length to hippocampal volume (data not shown in table).
However, the vessel density and tumor volume (data not shown) were similar between controls, WT BM-VPC and mDll4GOF BM-VPC tumors (Figure 7D).
For example, by simply advancing the surgery by 2 weeks to 6 week-old mice, MSC implantation no longer had a significant effect on striatal volume (data not shown).
Inhibition of EVs biogenesis could be an alternative approach; our preliminary studies using specific inhibitors of the PI3K-Akt signaling axis (e.g. LY294002), reveal a marked decrease in both the number of EVs and their volume (data not shown).
Similar(27)
However, post hoc analysis did not indicate significant differences between specific volumes (data not shown).
Comparable results were obtained if fluid given as nutrition was added to the fluid volumes (data not shown).
It was found that a template volume of 2 μl could be dispensed more accurately and reproducibly than 1 μl volumes (data not shown).
Similarly, there were no significant correlations between baseline or maximum PRL levels and postprandial symptoms or maximal ingested volumes (data not shown).
The same analysis was applied to the data sets from the 400 mL, MCC, and VV samples, but no association was shown between FDV and ATP release at these volumes (data not shown).
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