Image processing in the Rotterdam Scan Study has initially been centered around three main goals: First, owing to the sheer size and complexity of the imaging database being generated, we aim to automate the tedious task of manual analysis, both qualitative (e.g. use of rating scales, for example for cortical atrophy) and quantitative (e.g. manual contouring for volume analyses).
The fractional contour volume analyses was done by calculating for each animal the volume enclosed by the isosurface within each of the quadrants or row regions and dividing this by the total volume of the isosurface.
The following scans, when available, were used for the brain volume analyses: baseline, and months three, six, 12, 18, 24, and 36.
For the total volume analyses, we divided total volume by size of the population over 15 years old to control for population growth (using yearly population estimates from the World Bank 20).
This volume was analysed for bone volume (BV) and tissue mineral density (TMD).
The theory of Gaussian fields is used to provide P values that are corrected for the brain volume analysed [ 34, 35].
The composition dependence of the room-temperature average atomic volume is analysed for early and late transition metal (TE TL type) and metal metalloid (TL MD type) amorphous alloys.
The remaining volume was analysed for chemical parameters.
This volume presents extensive analyses for all carcinogens and occupational circumstances defined as definite or probable human occupational carcinogens by the International Agency for Research on Cancer.
As a result, imaging can segment specific anatomical structures such as basil ganglia, cerebellum, corpus callosum, and hippocampus to facilitate quantitative volume and shape analyses (for the definition of these and other terms, see Glossary).
