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This triggers internalization of the VLPs into the cells where the VLPs will open to release their cytotoxic cargo.
The result was the formation of a mixture of "geminate" and "single" virus-like particles (VLPs).
b, Indicated cell lines were infected with luciferase-encoding VLPs pseudotyped with H18 or H1N1, or control VLPs that lack any surface glycoprotein (empty vector).
VLPs are non-infectious and self-assembled nanoparticles derived from viral capsids.
For this purpose, virus-like particles (VLPs) offer several potential advantages.
The HepBc VLPs were further engineered to load and retain > 300 anti-cancer drugs per particle.
b DLS data of HBc VLPs.
b Electron micrographs of recombinant VLPs.
Consistently, the TLR3 ligand dsRNA complexed to CALV and in combination with VLPs (CALV(dsRNA)+VLPs) induced the strongest response.
Fig. 3 Characterization of CpG-Au@HBc VLPs and CpG@HBc VLPs.
Fig. 5 Induction of HBc-specific CD4+ and CD8+ T cells after immune with HBc VLPs, CpG@HBc VLPs, CpG-Au@HBc VLPs, CpG-Au + HBc VLPs, CFA/IFA + HBc VLPs, and PBS, respectively.
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