Sentence examples for vivo proof of from inspiring English sources

The in vivo proof of principle for weight loss with a lead compound from this series is exemplified.

This study represents the first in vivo proof of concept of closed-head iPDT guided by real-time MRI using targeted ultrasmall nanoplatforms.

In the preceding article, we have described a novel series of quinazolines as MCHR1 antagonists and demonstrated in vivo proof of principle with an early lead.

This new compound 21 could be used for an in vivo proof of principle to demonstrate the true therapeutic efficacy of 17β-HSD2 inhibitosteoporosisposteoporosis

The in vivo proof of concept of the hypothesis was tested in iron intoxicated male wistar rats intoxicated with iron dextran.

We also demonstrated, as the in vivo proof of concept, by pathological necropsy and NIS immunohistochemistry that these were spontaneous liver metastases from the orthotopic colon xenografts.

Subsequent optimization work in pursuit of the improvement of oral bioavailability demonstrated in vivo proof-of-concept by prodrug strategy based on phosphate esters for these 17β-HSD3 inhibitors.

Consequently, novel, APA-targeted, DXR-liposomes were developed and in vivo proof-of-principle was established, alone and in combination with APN-targeted DXR-loaded liposomes, in NB-bearing mice.

This technical issue did however not affect results and was considered not relevant in this ex vivo proof-of-concept.

This encouraging in vivo proof-of-principle was the basis for bringing the first dose of LiPlasomes in man.

Studies with Nutlins provided in vitro and in vivo proof-of-principle for targeting p53 MDM2 interaction for cancer therapy.