In vitro, both forms of these constructs are capable of binding cytokines, but in vivo only the non-crosslinked polymer significantly reduces markers of acute inflammation compared to controls that lack the antibodies.
In vivo, only traces of radiometabolites were detected in plasma during the entire 2-h period of the imaging study so that the parent radioligand remained close to 99% total blood radioactivity.
In the proof-of-concept study in which 152Tb was used for the first time in vivo, only 20 MBq of 152Tb were available after separation, allowing labeling of a DOTA-folate conjugate at a low specific activity of 1.3 MBq/nmol [1].
Usage of allogenic mesenchymal stem cells (MSC) could be permissible in vivo only if they retain their immune properties in an inflammatory setting.
We used a K12C mutant of histone H4 in our studies for targeted biotinylation of position 12, while in vivo only lysine residues are biotinylated.
In particular, it has been demonstrated that seizure-like activity was obtained in vivo only in case of blood brain barrier (BBB) leakage.
Intriguingly, when their suppression capability was tested in vivo, only p524-pulsed CD4+CD25+ T cells exhibited suppressive effects on diabetes development in co-transfer models.
Due to the short half-life of the molecule in vivo only cells dividing at the time of the injection or shortly after are stained [23].
Although expression of oncogenic K-ras in normal colonic epithelial cells can strongly activate ERK in vivo, only limited ERK signaling was observed in colon tumors that developed in these animals [10].
Moreover, our results indicate that the cleavage of the palindromic LTR-LTR junction is not tolerant to sequence modifications and thus is a highly specific reaction, whereas the integration sites, characterized in vivo, only exhibit a weak consensus.
However, they brought out a defect that remained subtle in vivo only visible through the morphological leading processes disorganizations around the floor plate, which is the abnormal extension in certain substrata.
