Sentence examples for vivo introduction from inspiring English sources

Cell-based vehicles are particularly attractive for delivery of bio-therapeutic agents that are difficult to synthesize, have reduced half-lives, limited tissue penetration or are rapidly inactivated upon direct in vivo introduction.

In vitro, tyrosine hydroxylase controls cytokine production in mixed synovial cells, whereas in vivo introduction of these cells into arthritic mice reduced arthritic score [ 87].

In this study, we intended to produce a new mouse model of renal failure using a simple and convenient method through in vivo introduction of non-viral DNA carrying a toxic gene such a diphtheria toxin A-chain (DT-A) gene.

Although a 1908-nt GU insertion did not significantly modify replication of wild-type PIV3 in vitro or in vivo, its introduction significantly augmented the level of temperature sensitivity (ts) and attenuation (att) specified by three mutations in the L protein of a cold-passaged attenuated PIV3 vaccine virus.

With further advances in biology and chemistry for imaging molecular targets and (patho physiological processes in vivo, the introduction of new imaging procedures and promising new radiopharmaceuticals in clinical practice may be accelerated.

Complementation of the dapAX mutation in vivo required the introduction of both genes in trans, either in single or multiple copy, and this restored the development of plague to near wild type levels.

Gene therapy can be used to re-direct T cells to specific TAAs by genetically manipulating the T cells ex vivo via the introduction of an exogenous TCR or a novel chimeric antigen receptor (CAR).

Inhibition of Stat3 activity in tumor-derived cell lines both in vitro and in vivo, by the introduction of antisense, small interfering RNA, decoy molecules, dominant-negative Stat3 constructs, and/or blockade of tyrosine kinases has been associated with growth arrest, apoptosis, decreased angiogenesis and invasion [ 2, 4, 8, 9].

Many tissue engineering studies thus opt to genetically engineer cells in vitro prior to their introduction in vivo.

Introduction: In vivo imaging of estrogen receptor (ER) densities in human breast cancer is a potential tool to stage disease, guide treatment protocols and follow-up on treatment outcome.

During bursting induced by SK block in vitro, spiking begins at a low frequency, but just prior to entry into depolarization block, often a burst of fast frequency, full amplitude spikes is emitted; these particular spikes may provide an in vitro analog of operationally defined bursts (see Introduction) in vivo.