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Two lead compounds from a series of novel phthalimido compounds, SIG343 and SIG353, showing high affinity and selectivity for the σ2 receptor in vitro were selected for further development of the 18F-labelled PET tracer.
On the basis of the literature search and ongoing international validation efforts by the OECD for methods to detect endocrine disruptive effects, 15 biological test methods (five in vivo and ten in vitro) were selected including eight OECD methods and three out of five in vitro methods mentioned in the Global Water Research Coalition GWRCC) report.
The Enterobacter strains that showed high AR activity in vitro were selected for the assessment of nitrogenase activity in planta by inoculation to Jatropha seedlings.
Experimental studies with PRP conducted in several species, both in vivo and in vitro, were selected if they were controlled and relevant to the clarification of the effects and mechanisms of action of PRP in tissues of interest.
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A panel of 78 field isolates of FCV grown in vitro was selected from samples submitted between October 2008 and February 2012 to the National Veterinary Institute in Sweden.
Trolox concentration used in murine (0.5 μM) and human (10 μM) ATII cells in vitro was selected based on the viability assay using trypan blue staining and MTT assay (data not shown).
We identified 199 bands that were differentially expressed among the three FOM strains grown in vitro, 75 of which were expressed uniquely in vitro and were selected for amplification and sequencing.
The top 2000 monocyte-expressed genes from the in vitro results were selected for the integrated proteomics in our study.
Because the MSLN-28Z and MSLN-28BBZ CAR-T cells displayed higher tumor lysis capacity and greater cytokine secretion than MSLN-BBZ CAR-T cells in vitro, they were selected for in vivo antitumor assays.
However, seven compounds (∼0.4% of compounds tested) did inhibit RNA synthesis by 3Dpol in vitro and were selected for further analysis.
The cell lines considered in our in vitro experiments were selected to represent different expressions of growth factor receptor and ERs.
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