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The variable to be optimized in vitro was the gentamicin release level during the first week.
The reason for the 'rescue' of the mutant phenotype in vivo and in vitro was the very rapid expansion of β1 integrin expressing keratinocytes in hpm skin.
A second and critical difference between the results in vivo and in vitro was the larger response amplitude from YC3.1 expressed in vitro in HEK cells (∼80%) compared to the CerTN-L15 expressed in mitral cells in vivo (∼26%).
They also found that the capability to proliferate T cells in vitro was the highest with LCs isolated on day 1 but low with those isolated on day 4 [15].
The potencies of steroid eye drops in MYOC induction in vitro was the same regardless of their potential for elevating intraocular pressure in vivo.
Proangiogenic capacity of S100A4 in vivo and its influence on endothelial cells' motility in vitro was the first indication of the extracellular significance of S100A4 in tumour progression (Ambartsumian et al, 2001).
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A technique to induce cytoplasmic uptake of proteins in vitro is the protein transduction using specialized protein transduction reagents.
The key factors for successful MSC proliferation and differentiation in vitro are the culture conditions.
A key challenge in engineering functional tissues in vitro is the limited transport capacity of oxygen and nutrients into the tissue.
The major challenge of working with valvular interstitial cells in vitro is the preservation or recovery of their native quiescent state.
The rate-limiting step in the mechanism in vitro is the release of the product (e.g. G : AP-site) due to rigid hydrogen bonding interactions between the enzyme and the Watson-Crick face of the guanine opposite the AP-site (Hardeland et al., 2000).
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