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A new family of indolizine chalcones was designed, synthesized and screened for the inhibitory potential on human farnesyltransferase in vitro to identify potent antitumor agents.
In the first step, a mycobacterial genomic DNA library was screened in vitro to identify plasmids encoding polypeptides that stimulate splenocytes from mycobacteria-immunized mice and T cells from PPD-positive healthy donors to produce interferon-γ.
The study was designed to assess the effect of deltamethrin on electrophysiological parameters of rabbit's skin, studied in vitro, to identify the mechanism of action and effects of short-term dermal exposure to deltamethrin.
In this study, a series of split DnaE inteins with new split sites have been constructed and tested for protein ligation both in vivo and in vitro to identify a functional split DnaE intein with a minimal C-terminal fragment.
The purposes of this study were: to investigate the effect of lactose and bile salts on bacterial adherence in vitro; to identify associated gene expression profiles of a set of ∼68 virulence-related factors; and to compare these results with the in vivo expressed genes from bacteria recovered from pig ligated intestine.
Replication assays were conducted in vitro to identify DNA pols capable of TLS past the model N-propyl-dG−peptide cross-links 26 83).
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Suggested for comprehensive screening using in vitro assays to identify critical mechanisms of toxicological action.
There is a need for relevant in vitro models to identify pathways that activate chemopreventive effects in the lung.
Our previous work applied a combination of bioinformatics approaches and in vitro assays to identify the dengue-2 virus (DENV-2 -specific DENV-2 -specificitopes.
The purpose of this study was to analyze the potential of placental-conditioned medium to activate endothelial cells in vitro and to identify the placental factors that mediate this effect.
Niosomes were prepared with different ratios between surfactant and cholesterol, and characterized in terms of size, morphology, drugs entrapment efficiency and in vitro releases, to identify the optimal formulation to be used in pharmaceutical fields.
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CEO of Professional Science Editing for Scientists @ prosciediting.com