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After identifying the complexity of each community (or modularity) within the MEA, the number of communities established in an in vitro system is quantified (Fig. 4b).
Absence of immune effect, blood proteins, the endocrine system and the general lack of complex interaction of the whole animal in most in vitro system is limiting the potential transfer of some cell culture-based results of nanoparticle studies to animals/humans [48].
This in vitro system is endorsed for investigation on kidney cell function, transport processes, and cellular mechanisms of proximal tubular injury by xenobiotics, without interference of other factors that are associated to in vivo experiments.
This underscores that the in vitro system is similar to the in vivo situation regarding this aspect.
We demonstrated that this in vitro system is a reliable model of the bronchial epithelium of human smokers.
1) Use of an in vitro system is sub-obtimal because of the potential loss of cell identity over time.
Similar(38)
An in vitro system was devised to determine if choline could bind to a significant degree to the dialysis membrane.
To further assess transvascular transport efficiency of these drugs, an in vitro system was carried out to mimic the endothelial cell monolayer.
An in vitro system was designed to investigate the effects of lead oxide particles of respirable size on the rabbit alveolar macrophage.
A method to predict GI using an in vitro system was compared to the in vivo system using a range of rice varieties differing in GI.
Its major biochemical characteristics based on enzymatic activities in the in vitro system were summarized in Table 1.
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