hESCs and iPSCs, which can be engineered reliably in vitro, provide an important new model system to study human lymphocyte development and produce enhanced cell-based therapies with the potential to serve as a "universal" source of antitumor lymphocytes.
We confirm that these functionalities have potency as inhibitors of G6Pase in vitro, providing a series of new phosphate isosteres that can be exploited for inhibitor design.
Recently, the developmental process was successfully recapitulated in vitro, providing a valuable tool for study of lacrimal gland development and possibly opening doors to regenerative therapy.
The collected dataset of estrogenic and androgenic activities in vitro provided a comprehensive basis to analyze and define structural alerts that can be used to screen for potential EA-EDs (Table 2).
In conclusion, glioblastoma development within a nervous tissue can be engineered in vitro, providing a relevant model to study the disease and allows the identification of clinically-relevant genes induced by the tumor/host tissue interaction.
In this study, we hypothesized that inhibition of TSP-2 in human aortic smooth muscle cells (HAoSMCs) would reduce cell proliferation and migration in vitro, providing a therapeutic target to mitigate intimal hyperplasia.
Differentiation of pluripotent stem cells in vitro provides a powerful means to investigate early developmental fates, including hematopoiesis.
The development of 3D, skin-like tissues in vitro provides a functional readout of stromal cell capacity to provide cross-talk needed for epithelial morphogenesis [30], [31].
Activin A increased the CCR10/CCR4 ratio on human cDC in vitro, providing a possible explanation for the accumulation of DC in the skin [ 63].
The ability to assemble these complexes in vitro provides a good starting point to investigate how additional host proteins may work with Crm1 during viral RNA trafficking.
