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T cell anergy induction has been proposed by some authors to require a single TCR stimulation in vitro or a single injection of an antigen.
Whether this inconsistency is a result of genetic evolution in vitro or a true reflection of variable significance of CD133 expression in the original tumors remains to be determined.
The hypolocomotor effects of transgene expression could be due to an elevated forebrain 5-HT2C receptor number, an increased ligand sensitivity of transgene-encoded 5-HT2C recepthe (the unedited isoform has a higher constitutive activity and an increased ligand sensitivity in vitro) or a combination of the two.
Such a significant time of pre-incubation with the ligands (from a few hours in vitro up to 72 h in vivo and cell-based systems) allows assuming that the experimental system reaches either an equilibrium (in vitro) or a steady state (in vivo).
Adequate therapy was defined by the receipt of a standard parenteral dose of an antimicrobial to which the organism was susceptible in vitro or a standard oral dose of an antimicrobial with sufficient bioavailability, to which the organism was susceptible in vitro.
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Winds could represent, for example, antigen stimulation or the addition of cytokines in vitro, or an infection or other environmental change in vivo.
Similarly, the same string must be used in the Factor Value column of the study file or assay file for material samples that are used as factors in an in vitro or an in vivo study.
Drugs and compounds that could potentially inhibit viral replication or virus protein synthesis can also be possible therapeutic agents, although at present the lack of an in vitro or an ideal surrogate system means progress in this area is slow [ 73].
Nanoparticles were sonicated for 30 min and used at a concentration of 125 500 μg/ml in vitro or at a concentration of 5 mg/kg in vivo, as mentioned.
The disulfide can then be reduced with DTT in vitro or with a thiol-disulfide oxidoreductase in vivo.
CDD1 of A3G is devoid of any cytidine deaminase activity (Figure 2) down to the 10−4 to 10−5 detection level characteristic of 3DPCR {Suspene, 2005 #332; Susp,} and supports the conclusions based on phenotypic analyses in vitro or in a mouse model [33].
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